Drug intelligence / Profile preview

[18F]F-RESCA-RND20

Development stage
Phase 1
Lead developer
KU Leuven
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

**[18F]F-RESCA-RND20** is an investigational fluorine-18-labeled immunoPET radiotracer designed to bind **Nectin cell adhesion molecule 4** and enable noninvasive PET/CT visualization of Nectin-4 expression in tumors. It is being evaluated as a diagnostic imaging probe in the recruiting, phase-not-specified NCT06715839 study of patients with digestive system carcinomas; the study assesses tracer biodistribution, tumor uptake, and preliminary diagnostic performance after injection. It is a diagnostic radiopharmaceutical rather than a therapeutic radioligand. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06715839))

Other names
[18F]F-RND20
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))PDGFRB (Platelet-derived growth factor receptor beta)

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